Scott Sellars' Under 23 side are currently in third place in the Premier League 2 table, with two games in hand over second-placed Newcastle United and one game in hand over league-leaders Swansea City.
They approach Monday night's game on the back of a 1-0 win over local rivals, West Bromwich Ablion. Connor Ronan the goalscorer with a sublime free-kick.
Wolves Under 23s and West Ham Under 23s shared the points in a 2-2 draw in the reverse fixture back in September.
The Hammers approach the game without a win in three PL2 outings, falling to a 3-2 defeat in their last outing at home to Swansea City.
Tickets for tonight's game are £5 for adults, £1 for concessions and entry is free if you are a Wolves season ticket holder.
WOLVES
Daniel Armstrong, C. Borthwick-Jackson, Anthony Breslin, Rory Brown, Nicu Carnat, Joe Delacoe, Sylvain Deslandes, Ross Finnie, Jon Flatt, Morgan Gibbs-White, Christian Herc, Connor Johnson, Ryan Leak, Conor Levingston, Joe Mason, Prince Oniangue, Will Randall, Jack Ruddy, Aaron Simpson & Mike Williamson.
