The forward replaced Joao Felix with 15 minutes remaining of Portugal’s 3-0 Nations League victory over Sweden.
The result also saw Rui Patricio claim another clean sheet between the sticks, while Joao Moutinho featured as a late substitute.
At the same time, Conor Coady earned his third international cap, playing the full 90 minutes of 10-man England’s narrow defeat to Denmark at Wembley.
On Tuesday Adama Traore started in Spain’s 1-0 defeat to Ukraine, as did Raul Jimenez in Mexico’s 2-2 draw with Algeria.
Portugal under-21 duo Pedro Neto and Vitinha were also in action against Gibraltar, with the former replacing the latter 63 minutes into the 3-0 victory.
A day earlier Rayan Ait-Nouri came on just before half-time of France under-21s’ win over Slovakia.
Now, all players return to Wolverhampton, and attention turns to a Premier League trip to Leeds United.
