The Under 18s began their Premier League U18 campaign with a 1-1 draw against local rivals West Bromwich Albion last Saturday.
Saturday’s opponents finished top of the Premier League U18s table last season and began this season’s campaign with a 2-1 win away at Newcastle United.
Despite the tough opposition, Ryan is confident ahead of the trip to Manchester.
He said, “It certainly gives us a different challenge - we know it’s going to be difficult but we’ve got good players in our team.
“It’s been a great week in training - we as staff have had to pick them up a little bit after Saturday, after conceding in the last minute but the positives outweighed the negatives.
“We’ve gone through it and analysed it and we move on, and we start looking to Man City on Saturday. I’m confident and the lads are confident that we will cause them problems.
“Overall I thought we dominated the game last week - we just needed the second goal to go in, I think that would have seen the game out.
“It’s good learning for them, it’s good development about how to manage a game. It shows them that you've got to be switched on for the whole 90 minutes.
“With the players that we’ve got, we will approach the game as if we want to win it.
“We’ve got good attacking players, we’ve watched them, we’ve worked on things in training and it’s just about implementing those things on Saturday.
“They have got good players but we’ve got good players at this football club and it’s a good test.
“The lads are really up for the game and hopefully the things we’ve worked on will come out in the game.”
Ryan is hoping to have as similar squad as possible that he had for last week’s draw with West Brom.
Taylor Perry and Terry Taylor will miss the game due to being on international duty.
Brad Carr has been struggling will an illness but Ryan is hoping that last week’s goalscorer will be fit to play on Saturday.
“We’ve lost Taylor Perry and Terry Taylor who have gone on international duty - Perry with England and Taylor has gone with Scotland.
“Brad Carr has had an illness but he trained on Friday and he’s come through that - we will just have to see how he gets on.
“He’s an important player for us and of course he wants to play - we’ve obviously done everything possible to try and get him through the game.”
