Scott Sellars' side approach the game on the back of a disappointing 5-1 defeat against Blackburn Rovers in the opening fixture of the season at Ewood Park last Monday.
Speaking after last week's fixture, Sellars said: "I’m disappointed and quite embarrassed really - that is not good enough for what we expect and there will be changes for our next game."
Tonight's opponents opened their season with a 4-0 win over Reading at St Mary's through goals from Tyreke Johnson, Jonathan Afolabi (2) and Gabriel Osho.
Discussing the victory with southamptonfc.com, double-goalscorer, Afolabi said: “It was a great performance from everyone. We put in a shift right from the beginning tonight and got the reward for it.
“Personally, I was really pleased to also get two goals. It was a good way to boost my confidence and start the season.”
Tickets for tonight's game are priced at £5 for adults, £3 for concessions and £1 for U16s. Admission is free for Wolves season ticket holders.
Wolves
Harry Beasley, Harry Burgoyne, Anthony Breslin, Cameron John, Connor Johnson, Ryan Leak, Dan Armstrong, Ross Finnie, Pedro Goncalves, Christian Herc, Carlos Heredia, Ryan Rainey, Sherwin Seedorf, Andrew Sealey-Harris, Jordan Allan, Aaron Collins, Will Randall, Donovan Wilson.
