"The thoughts of everyone at the Premier League are with all those directly affected by COVID-19," said Premier League chief executive Richard Masters.
"In response to the pandemic, the League, our clubs and players are providing valuable support for communities and the NHS.
"We are also aware of the importance of finding new ways to entertain fans at this time and we are excited to bring together a strong line-up of players for the ePremier League Invitational tournament.
"With Sky Sports screening the competition live in the UK and many of our international broadcast partners also showing the matches, fans around the world can tune in and enjoy the action.
"We know how popular FIFA 20 is with players and I am looking forward to seeing who will be crowned the ePL Invitational champion."
Jota and Ndidi are joining the likes of Raheem Sterling, Trent Alexander-Arnold and Wilfried Zaha, who will all represent their respective clubs.
The opening rounds take place between 21st and 24th April, before the semi-finals and final take centre stage on Saturday 25th April.
Wolves fans will be able to watch the action throughout the week on Wolves TV.