Morocco and Senegal secured vital victories to seal top spot in their African qualification groups.
Saiss’ Morocco will compete in their first World Cup since 1998, after a 2-0 victory over Ivory Coast proved decisive, with the Wolves midfielder playing the full 90 minutes.
As for Senegal, they beat South Africa twice in a week to secure only their second ever World Cup appearance. N’Diaye came off the bench in the first game, a 2-0 win, before starting the 2-1 success which followed days later.
There was no joy for Matt Doherty however, as the Republic of Ireland failed to proceed from their Play-Off with Denmark. The Wolves man was unused in both games, as Ireland suffered a 5-1 reverse after a goalless draw in Denmark.
There was however, a senior international debut for Ruben Neves, who came off the bench in both of Portugal’s friendlies against Saudi Arabia and USA over the weekend.
Prince Oniangue captained Congo in their final World Cup qualifier against Uganda. The fixture finished 1-1, which confirmed Congo would finish bottom of their group.
Alongside the senior internationals, Diogo Jota and Connor Ronan were representing their countries in the UEFA Under-21 Championship qualifiers.
Jota captained Portugal to four points from six available, drawing 1-1 in Romania, before a 2-1 success at home to Switzerland, where the Wolves man hit the back of the net.
However, the Republic of Ireland were knocked off top spot in their qualifying group after a 2-1 defeat at Norway, which saw Ronan play four minutes as a late substitute.
Left-back, Ruben Vinagre started for Portugal's Under-19s side on Tuesday, as they beat Spain 2-1.
Finally, Lee Evans, who is on loan at Wigan Athletic from Molineux, made his international debut for Wales on Tuesday, as they drew 1-1 at home to Panama in an international friendly.