Bruno Lage’s men will face the fellow Premier League side the week commencing 20th September 2021 at Molineux.
Victory over Nottingham Forest on Tuesday evening secured Wolves’ safe passage through to the next round, while Spurs enter at this stage due to their involvement in Europe.
The tie will be the second time Wolves and Spurs have clashed already this season, with the North Londoners winning in the West Midlands last Sunday.