Manchester United 5 (Evans 21, Valencia 43, Welbeck 45, Hernandez 56, 61)
After an evenly fought out opening against reigning Premier League Champions Manchester United, Wolves fell behind and were then reduced to ten men shortly before the break with Ronald Zubar being dismissed following two yellow cards.
Things then went from bad to worse as four more goals were conceded without reply resulting in another heavy Molineux defeat.
Terry Connor made just one change to the team that had lost to Blackburn with Kevin Foley coming in for the injured Jamie O'Hara.
Wolves kicked-off attacking the South Bank end and in their first attack Zubar over-hit a right wing cross whilst United's first attempt at goal was a low shot from Danny Welbeck that was easily dealt with by Wayne Hennessy.
But there was serious danger just seconds later when Rafael Da Silva cut in from the left and hit a low cross that was just too far in front of Javier Hernandez.
Kevin Doyle's shot on the turn from the edge of the box didn't carry the power to trouble David De Gea in United's goal and then Michael Carrick drilled a shot wide of the far post when play switched to the other end.
Penalty appeals after Da Silva collided with Matt Jarvis in the United box were unanswered then Steven Fletcher was just off target with a glancing header following a cross from Jarvis.
But, after almost taking the lead, Wolves fell behind in the 21st minute. Wayne Rooney's corner fell to Carrick at the far post and when he turned the ball back into the six-yard box, Jonny Evans was there to turn it over the line from close in.
Zubar was booked for a late challenge on Rooney but when Da Silva clattered into Doyle just a minute later, there was no card.
With 39 minutes gone the mountainous task facing Wolves grew even greater as Zubar caught Welbeck and was shown a second yellow. Foley moved from midfield into the right-back slot.
David Davis, who had picked up a rib injury, was replaced by Eggert Jonsson before United took the game out of reach with two goals in two minutes before the break.
United broke from a Jarvis corner and Antonio Valencia raced down the right flank before cutting into the box and lashing a shot into the roof of the net.
In stoppage time Valencia turned to creator as he set up Welbeck who ran in andj slid the ball past Hennessey.
Half-Time: Wolves 0 United 3
After the resumption, the ten men tried hard to find a way through United's defence and a Fletcher head down into the heart of the box after a floated free-kick from Jarvis, fell to a defender and was cleared.
On 56 minutes Hernandez headed United's fourth from close range after a centre from the right by Da Silva.
Almost immediately Michael Kightly replaced Doyle but the misery for Wolves continued in the 61st minute as Hernandez thumped a shot into the roof of the net after Valencia had delivered a low cross.
Midway through the half De Gea was forced into action with two saves inside a minute. He was at full stretch to palm away a low shot from Kightly and, when Jarvis returned the ball into the middle, Fletcher's powerful header had the keeper diving the other way.
But United were soon back on the look-out for more goals and Hennessey had to save with his feet to deny Welbeck with ten minutes remaining.
Despite the depressing scoreline, Wolves were roared on by some tremendous vocal support from their fans who kept it up right until the final whistle.
Wolves: Hennessey, Zubar, Ward (capt), Edwards, Bassong, Stearman, Doyle (Kightly 57), Davis (Jonsson 43), Fletcher(Ebanks-Blake 77), Foley, Jarvis.
Unused subs: Johnson, Berra, De Vries, Hunt.
Booking: Zubar (28 - foul).
Sending-Off: Zubar (39 - second bookable offence - foul).
United: De Gea, Evra (capt) (F. Da Silva 63), Ferdinand, Evans (Smalling 74), Rooney, Hernandez, Carrick (Pogba 57), Welbeck, R. Da Silva, Scholes, Valencia.
Unused subs: Giggs, Park, Young, Amos.
Booking: Welbeck (67 - foul).
Referee: A. Taylor.
Leeds United Academy Under 21s 4 Wolves 1 (Kempton)