Tottenham Hotspur 2 (Adebayor 67, Defoe 80)
For just over an hour this was a game of end to end action with both Wolves and Spurs playing some neat, flowing football. But it was the Londoners that stole the show with two goals in the final 23 minutes to inflict a first defeat of the season on Mick McCarthy's men.
There was just one change to the Wolves line-up with Michael Kightly coming in for Matt Jarvis who had been recovering from an ankle injury and was named a substitute.
Spurs kicked-off attacking the South Bank end and they won a corner after just 20 seconds with Kevin Doyle heading away Niko Kranjcar's flag kick.
Then a Jermain Defoe shot was deflected behind and this time Kranjcar's corner sailed over a crowded box and out behind on the far side of goal.
Wolves responded with a cracking cross from Stephen Ward that the visiting defence struggled to clear, and a long range effort from Stephen Hunt that lacked the power to trouble Brad Friedel in the Tottenham goal.
Spurs almost took the lead after nine minutes when Benoit Assou-Ekotto's low cross hit Roger Johnson and was deflected towards goal. Wayne Hennessey managed to knock the ball away but only as far as Kranjcar whose follow up was brilliantly kicked off the line by Richard Stearman who was running in facing his own goal.
Moments later Stearman dispossessed Kranjcar inside the Spurs half and took the ball to the edge of the box before slipping a short pass to Jamie O'Hara whose first time shot was beaten way by Friedel.
Karl Henry won a challenge on the halfway line and raced to the Tottenham box slipping inside a defender before hitting a shot that was destined for the far corner until Friedel dived full length to turn it behind.
Kightly had a header saved by the American following a cross by Hunt who then jinked his way into the area between Ledley King and Assou-Ekotto only to stumble as he was about to shoot.
Henry was harshly deemed to have obstructed Kranjcar some 25-yards out. The Croatian took the free-kick himself and then the corner that followed after his shot took a deflection off the wall. From the corner, King bounced a header over the bar.
Kyle Walker went into the book for dissent after he was penalised for a challenge on Doyle to the left of the Tottenham area. Kightly lifted over a dangerous free-kick and Johnson climbed high at the back post to send a header just the wrong side of the woodwork.
Spurs threatened twice in the closing minutes of the half. O'Hara lost possession to Defoe whose low shot was turned around the post by Hennessey, then Gareth Bale beat the offside trap as he ran into the home area before shooting into the side netting.
Half-Time: Wolves 0 Spurs 0
In the early stages of the new half, Hennessey had to race from his area to hack clear as Emmanuel Adebayor ran through, before a Hunt cross was headed out by Scott Parker but only as far as O'Hara who tested Friedel with a first-time shot from 20-yards.
In the 50th minute, Luka Modric fed Defoe who squared the ball to Bale but Henry nipped in to clear just as the Welsh midfielder looked likely to opening the scoring.
But, with the half midway through, Tottenham moved ahead, Parker slipped the ball through to Adebayor who skipped around Hennessey before planting the ball into the empty net.
Parker then went into the book for tripping Kightly but O'Hara's free-kick was cleared. With 15 minutes remaining, Wolves switched Adam Hammill and Jarvis for Kightly and Hunt.
Five minutes after his introduction, Hammill was booked for a push on Parker and from the resulting free-kick, Spurs went two up.
The ball was played to Defoe who then took a return pass from Kranjcar before hammering the ball past the diving Hennessey.
Sam Vokes took the place of Steven Fletcher, and Johnson was booked for a heavy challenge on Defoe as the game approached what was a disappointing conclusion for the home support.
Wolves: Hennessey, Stearman, Ward, Henry, Berra, M. Johnson (capt), Kightly (Hammill 75), O'Hara, Doyle, Fletcher (Vokes 80), Hunt (Jarvis 75).
Unused subs: Elokobi, Milijaś, De Vries, Foley.
Bookings: Hammill (79 - pushing), Johnson (83 - foul).
Spurs: Friedel, Bale, Kaboul, Parker (Livermore 84), Adebayor, Modric, Defoe (Dos Santos 89), Kranjcar, King (capt), Walker, Assou-Ekotto.
Unused subs: Pavlyuchenko, Bassong, Cudicini, Townsend, Falque.
Bookings: Walker (35 - foul), Parker (67 - foul).
Referee: P. Walton.
Wolves Academy Under 18s 2 (Ismail, McAlinden) Sheffield Wednesday 1