Wolves visit Brighton's Amex Stadium for the first time on Saturday, needing a big win to have any chance of staying in the nPower Championship.
The two clubs have seen wildly differing seasons, with Wolves' woes in sharp contrast to the Seagulls' impressive campaign, which has already seen them guarantee themselves a play-off spot.
However, the sides were separated by just two points when they met in the reverse fixture in November.
A thrilling encounter was served up at Molineux, with Roger Johnson's late equaliser salvaging a 3-3 draw for ten-man Wolves.
Wolves had gone in front twice that afternoon, through Bakary Sako and Tongo Doumbia, but Brighton had levelled on both occasions and, after Karl Henry had been sent off, the visitors thought they had won it through Stephen Dobbie's 89th minute penalty, only for Johnson to head home a last-gasp leveller.
Before this campaign, the sides were last in the same division during the 2005/2006 season, again in the Championship.
Wolves took four points from the Seagulls that season, with Colin Cameron's late goal earning a draw at the Withdean Stadium before a Kenny Miller penalty was enough to give Wolves all three points at Molineux in the season's penultimate game.
The fixtures in the previous campaign followed a similar pattern, with Wolves this time being held to a 1-1 draw at home after Miller again had been the difference between the sides on the south coast.
Brighton last triumphed over Wolves during the 2002/2003 season - the campaign in which Wolves would go on to claim promotion - hammering Dave Jones' side 4-1 at the Withdean, with Bobby Zamora among the scorers.
Miller again registered what was only a consolation goal that day, giving the Scot a superb record of five goals in six games against Brighton while playing for Wolves.
Of the last ten games between the sides, Wolves have won three, Brighton two, and five have ended all square.
Gus Poyet's current Brighton squad includes former West Bromwich Albion goalkeeper Tomasz Kuszczak, along with ex-England internationals Wayne Bridge and Matthew Upson.
Their goal threat has been shared around during this campaign - only Craig Mackail-Smith has hit double figures in the league, but he has been supported by contributions from the likes of David Lopez, Ashley Barnes, Jose Ulloa and Will Buckley - who along, with Mackail-Smith, scored at Molineux earlier in the season.