Wolves travel to The Den tomorrow evening to take on Kenny Jackett's Millwall (7.45pm).
The Lions, who lost at Elland Road at the weekend, have been in indifferent form of late, dropping down to 14th in the league after enjoying a thirteen-game unbeaten run during the final months of 2012.
That run included a 1-0 victory at Molineux, in which former Wolves striker Andy Keogh hit the winner late on.
That was the first league meeting between the sides in over six years, although Millwall did visit Molineux last season for a third round League Cup tie.
Dave Edwards, Adam Hammill and George Elokobi were all on target during a one-sided first half, before late goals from James Spray and Adlene Guedioura wrapped up a 5-0 win.
Wolves' last league win over the Lions came in January 2005, when the newly-appointed Glenn Hoddle saw his side win on their travels for the first time during his reign, thanks to a last minute winner from Seol Ki-Hyeon.
Of the last twenty meetings in all competitions, Wolves have won eight, Millwall seven, and there have been eight draws.
Among those eight Wolves wins was the memorable 3-0 triumph at Molineux during the closing weeks of the 2002/2003, as Dave Jones' side continued their march towards what was ultimately a successful play-off campaign.
A Shaun Newton double and a well-taken Colin Cameron effort sealed the points that day, with Wolves going on to finish fifth and claim promotion at Cardiff's Millennium Stadium.
Of the current Wolves line-up, Jamie O'Hara will be back in familiar surroundings tomorrow - the London-born midfielder had a brief loan spell at Millwall during the 2007/2008 season, before he broke into the Tottenham Hotspur first team.
He is likely to line up tomorrow against Keogh, the striker who spent five years at Molineux - helping the club into the Premier League in the process.
After signing from Scunthorpe United in 2007, the Irishman played over 100 games for Wolves under Mick McCarthy, before joining the Lions during the 2012 January transfer window.
Among Keogh's most memorable contributions in a Wolves shirt were the double he scored against Derby County as Wolves closed in on the Championship title in 2009, and the assist he provided for Sylvan Ebanks-Blake's promotion-clinching goal against QPR the following week.
He was also Wolves' first goalscorer of the 2009/2010 Premier League campaign - nodding home an early winner as McCarthy's team beat Wigan 1-0 in their second game of that season.