Wolves welcome Watford to Molineux for Friday night's televised nPower Championship clash as they look to secure the result that would move them out of the bottom three.
At the other end of the table, Gianfranco Zola's side are chasing promotion to the Premier League, and they currently occupy the second automatic spot, level on points with third-placed Hull City but ahead due to their far-superior goal difference.
When the two sides met earlier in the season at Vicarage Road, Watford ran out 2-1 winners after Wolves were reduced to ten men early on.
Christophe Berra received his marching orders after a tangle with Troy Deeney, and the decision proved a crucial one as Watford took control of the game, opening the scoring ten minutes later through Nathananiel Chalobah.
A mistake from Hornets goalkeeper Manuel Almunia allowed Bakary Sako to equalise early in the second half, but Deeney headed home the winner on 70 minutes.
Prior to that game, the last meetings between the sides came in the 2008/2009 season, when Wolves did the double over Watford on their way to promotion.
The first clash of that season came at Vicarage Road, when Wolves - wearing an unusual combination of black shirts and gold shorts - ran out 3-2 winners after an enthralling game.
Chris Iwelumo opened the scoring in the opening seconds, but Watford drew level on 20 minutes through Grzegorz Rasiak.
The two sides again traded goals either side of half time - Dave Jones with the second for Wolves - before Tommy Smith blazed a penalty kick over the bar and Michael Gray settled the clash with twenty minutes remaining.
The teams met again at Molineux in late January, with Wolves claiming their first win in six games to get their promotion push back on track. Sylvan Ebanks-Blake, Andy Keogh and Sam Vokes were all on the scoresheet as Wolves won 3-1.
Before that, Wolves' last league win against the Hornets came in August 2001, with Watford unbeaten in ten league meetings in the intervening seasons.
In the last twenty games in all competitions, both teams have won six times, with the other eight meetings finishing all square.
This season, Watford have the best away record in the division, having won ten times on their travels so far - including a thumping 4-0 victory at Birmingham City in their last visit to the Midlands.
Wolves fans will recognise one member of the Hornets squad, Geoffrey Mujangi-Bia - the young Belgian signed by Mick McCarthy during the 2010 January transfer window.
Mujangi-Bia made just four league appearances during his time at Molineux, and signed for Watford on a season-long loan from Standard Liege at the start of this campaign.